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Poster Abstract

Glucose Independent Xylose Metabolization in Escherichia coli

N. Johnson¹, G. Lynch¹, G. Tobin¹, L. Weiss¹, M. Marshall², P. Cirino³, D. Farber³, T. Richard³, P. Weiss³

¹Undergraduate Student, The Pennsylvania State University
²Graduate Student, The Pennsylvania State University
³Faculty, The Pennsylvania State University

The innate tendency of common ethanologenic bacteria to sequentially metabolize sugars, known as diauxie, complicates the recovery process and hinders the profitability of biomass energy conversion. The practicality of ordinary plant biomass digestion would be greatly improved by modifying the control of catabolite repression proteins on the metabolic pathway of the common lignocellulose sugar xylose. We are exploring two promising ways to achieve this goal without hindering cell growth: selectively modifying the regulatory and promoter region of the xylose genes, and employing a mutant metabolic regulatory protein.